Sustained-release kinetic measurements

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Dr. Jobbágy Ákos Andor
Department of Measurement and Information Systems

In this study we searched for possible solutions of septic articular prosthesis, such as bone grafting and bacterial infection, because these are still unsolved problems in the clinical practice nowadays. In orthopaedic surgery the most fequently occurring serious complication that bacterial infections cause is wound suppuration. Pathogens responsible for the infections are staphylococcus, streptococcus, pneumococcus, enterococcus. The developed infection can lead to bone degradation. Therefore we looked for antibiotic coatings, which can provide prolonged drug release from the bone surface. The advantage of the drug carrier systems is local antibiotic release, so we can achieve effective concentration in places where orally and intravenously administered antibiotics cannot produce effective treatment. The drug release system was prepared with sodium alginate and pectin. We choose vancomycin as the antibiotic to realise the prolonged drug release. For the investigation, the used devices were freeze drier and UV-Vis spectrophotometer, automatic pipette or syringe pump. The used bone was derived from human femoral heads. We coated the bones with vancomycin int he first step,then we put a double layer of a sodium alginate and pectin mixture. We investigated various compositions of sodium alginate and pectin coatings in order to characterise the effect of the complex compositions on the drug release. We described the performed tests in detail. The aim of this study was to prepare antibiotic coatings, which provide prolonged drug release from bone surfaces, and to investigate drug release kinetics in in vitro tests.


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