Characterisation measurements in microreactor cells of Lab-on-a-Chip devices

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Supervisor:
Dr. Ender Ferenc
Department of Electron Devices

Microfluidic devices are special types of Micro-Electromechanical Systems (MEMS). Microfluidic solutions and microfluidics-based chip-scale devices are becoming increasingly popular in modern medical diagnostics. The so-called Lab-On-a-Chip systems constitute a new generation of these devices.

Solutions for biomedical procedures commonly use bio-receptor molecules attached onto magnetic nanoparticles. The separation of unnecessary molecules from the nanoparticles trapped in external magnetic field can be easily done by the flow of the carrier fluid. The development of a magnetosensor has been started at the Department of Electron Devices, with the goal of quantifying nanoparticles in the reaction chambers of Lab-On-a-Chip devices.

In my thesis work I present literature on the topic, such as the basics of microfluidics and the use of nanoparticles. I demonstrate the principles and the operation of the magnetic nanoparticle balance. I designed a magnetosensor based on the previous results of the Department’s research group. The new magnetosensor is based on a printed wiring board technology. The device aimed to reduce or to entirely eliminate the problems associated with the handmade magnetosensor. I also designed and implemented a sensor readout circuit with the aim of further reduce the instrumentation and cost requirements, and to increase the sensitivity of the measurement.

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