Diabetes mellitus is a condition in which the body permanently fails to regulate the amount of glucose in blood plasma, this way causing severe complications leading to various organ failiures, coma or even death. Nowadays diabetes mellitus is still uncurable, thus the treatment concentrates on keeping the blood glucose level under tight control. The best way to achieve this is based on an accurate mathematical model of the glucose metabolic system controlled by a theoreticaly sound, efficient controller unit.
After the introductory chapter of the modeling of the glucose metabolic system, models will be compared and presented, which can later form the foundations of an efficient open-loop control stystem.
The next chapters will discuss the theoretics and implementation of a nominal and robust version of NMP Controllers. Based on the results the possibility of applying the controllers in future blood glucose regulating systems will be assessed.
Evaluating the test results of the in silico system will bring us closer to the realization of future blood regulating products which would be able to improve the lifestyle and increase the comfort level of millions of people.