Investigating fluorescent labeling in bioaffinity assays

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Supervisor:
Berényi Szilvia
Department of Inorganic and Analytical Chemistry

The aging population and its accompanying increase in chronic disease prevalence put high pressure on the healthcare system. The number of the patients to be cared is continuously rising, so there is a need for easy-to-use and cost-effective medical technologies which also provide rapid results. To accomplish these requirements, there is the so called Lab-on-a-Chip (LoC) technology developed for the Point-of-Care Testing (PoCT) systems. [1]

The principle of the LoC technology is to integrate the testing processes of the monumental laboratory diagnostic systems and to minimize them on a chip. The advantages of this method are the following: only a drop of sample is needed, the preparation, separation and analytical processes are evaluated on chip, so the results can be available in a short time. For the enhancement of the detection sensitivity in the LoC based tests, a broad range of labeling materials can be used.

This study is a part of a project, in which a microfluidic LoC technological, quantitative diagnostic device is to be developed. In the engineered sensor the detection of the relevant biomarkers will be realized by synthetic receptors and fluorescent nanoparticles with optimal properties for the detection and to characterise the bioaffinity assay to be used in the device.

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