In my dissertation I demonstrate the procedure of dialysis that is used to treat chronic kidney disease and the main types of dialysis such as hemodialysis, peritoneal dialysis, hemofiltration, hemodiafiltration and hemoperfusion are described. First, the structure and principle of a general dialysis machine is reviewed, then the focus will be on the different realizations of hydraulic systems. After that I explain the essentials of control systems that are applied to create dialysis fluid, paying particular attention to Smith predictor structure. The theoretical part ends with the description of the software and devices with which I have worked.
In the experimental chapter of my work I write about the selection of valves that are used to dose the concentrate. The plant model is also explained that I prepared in Matlab Simulink including the various kinds of measurements that I performed during my work. In the next part of the dissertation the simulation of the completed model is presented with the indication of the results. Based on my experiences I also write about the requirements toward hardware, and investigate whether the model works like a real system. After presenting the steps how a Smith predictor based controller is designed, it is shown how the selected hardware components were built into the dialysis machine. Furthermore, I describe the identification of the prepared system and the operation of the software that I have made for automatic identification, and finally the results of the identification process are presented. In the following chapter I show the steps how my controller was designed for the entire system; moreover, I give details of the implementation of the software. At the end of the dissertation the testing process of the completed system is described and the tasks are highlighted that I would like to accomplish in the future.