Lab-on-a-Chip (LoC) devices, promises solutions for high throughput
(100-1000 tests/hour) and specific analysis for chemistry, biology and medicine, while consuming only tiny amounts of samples, reactants and space. The amount used is typically a drop of blood (which is around 6 µl), but in certain cases, for instance in cellular analysis, only 1 nl could be enough. The main part of applications corresponds to general research, DNA analysis, DNA amplification, clinical diagnosis, drug development and few applications in the fields of environmental and food analysis.
In the field of Lab-on-a-Chip devices, we can encounter several biodetection applications based on optical sensors. Beside conventional fluorescence methods, the use of focused laser beam is getting a great significance as well. Using focused laser beam, cell or particle detection and manipulation can be achieved. A possible way to position the laser beam precisely is using an integrated optical waveguide chip. The aim of my project is to develop a method, which allows to integrate optical waveguide system in polydimethylsiloxane based chips.