Multivariate statistical and causal analysis of therapies in malignant melanoma

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Dr. Antal Péter
Department of Measurement and Information Systems

Malignant melanoma is a connective tissue related tumor, origined from melanocits, the pigmented cells of the skins’ basal layer or from a pigmented naevus. In Hungary, the number of patients suffering from melanoma related skin cancer is more than two thousand, from which approximately four hundred is lethal. From the end of the nineties the proportion of lethal cases were optimized thanks to an intervention called sentinel lymph node biopsy, which was put to the melanoma treating protocol. This minimally invasive intervention was developed in the beginning of the nineties, now it is widely used in breast cancer and other epithelial related cancer treatment. According to literature, at the time of the discover, 85% of newly diagnosed melanomas is clinically localized, so to determine the tumoruos status of the regional lymph nodes in a melanoma is one of the most important prognostic factors, furthermore it is an essential factor in decideing additional oncotherapy.

During my work, I examined the correlations between patients’ sentinel lymph node status and other different prognostic factors, and made statistical survival analysis, based on different factors.


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