Artificial matrix preparation, characterization and in vitro tests for biomedical applications

OData support
Supervisor:
Dr. Jedlovszky-Hajdú Angéla
SE Biomedical Engineering MSc

Huge amount of polymers are used for a wide range of medical or pharmaceutical purposes. They’ve been used as contact lenses, prosthetics or additives of drug substances. The technology, and new materials we have now are always being developed for the better or for new purposes. For the bases of such materials are coming from polymers which can be found in nature. We expect from these polymers to be biocompatible and biodegradable, so not to cause immune reaction and after degradation build into our system. Poly(aspartic acid) can be a good choice for medical application, which can be created from polysuccinimide by alkalaine hydrolyzation.

Nanotechnology is one of the most intensively developed discipline. With its help, we can create artificial matrices which have fibre diameters like in the living organism. Among other technologies, the method of electrospinning is good for creating such fibres. We can modify fibre parameters by adding silver nanoparticles or salts. With different setups, modifications, 3D structures have been experienced but for the causes there is no universal explanation yet. The questions need to be answered to make this process reproducible because there is a lot of potential uses for this 3D structures. With the change of electric field or the shape of the collector similar effect can be reached.

My aim was to create artificial 3D fluffy fibre structures from poly(succinimide) with the help of electrospinning. Therefore I investigated the effect of the presence of silver nanoparticles and salts on the process of creating fibres. With the help of a 3D printer I created unique collector shapes and examined their usability and the effect of the geometric parameters on creating fibres.

Downloads

Please sign in to download the files of this thesis.